Test Catalog

Advanced Toxicology Service

Test Code: T51

The T51 Advanced Toxicology Service is a combination of High-Resolution, Accurate Mass (HRAM) Library Screening and targeted Ultra-High Performance Liquid Chromatography with Tandem Mass Spectrometry (UHPLC-MS/MS) screening with UHPLC-MS/MS quantitative confirmation of positive analytes. This package includes quantification of > 225 common, illicit, and novel drugs and can be used to aid in determination of cause of death where there is suspicion of drug or pharmaceutical toxicity. This service includes quantification of volatiles.

Analytes Tested

  • Δ8-THC
  • Δ9-THC
  • 2-Methylacetyl fentanyl
  • 4-ANPP
  • 4F-MDMB-BUTINACA
  • 5F-MDMB-PICA
  • 5F-MDMB-PINACA
  • 9-Hydroxyrisperidone
  • 11-Hydroxy-Δ9-THC
  • 11-Nor-9-Carboxy-Δ8-THC
  • 11-Nor-9-Carboxy-Δ9-THC
  • 6-Acetylmorphine
  • 7-Aminoclonazepam
  • 7-Aminoflunitrazepam
  • 8-Aminoclonazolam
  • AB-FUBINACA
  • Acetaminophen
  • Acetone
  • Acetyl fentanyl
  • Acryl fentanyl
  • ADB-PINACA
  • Adinazolam
  • Alfentanil
  • alpha-Hydroxyalprazolam
  • alpha-Hydroxyetizolam
  • alpha-PiHP
  • alpha-PPP
  • alpha-PVP
  • Alprazolam
  • Amiodarone
  • Amitriptlyine
  • Amoxapine
  • Amphetamine
  • Aripiprazole
  • Atorvastatin
  • Atropine
  • Baclofen
  • Benzyl fentanyl
  • Benzoylecgonine
  • Brexpiprazole
  • Bromazepam
  • Bromazolam
  • Brorphine
  • Buprenorphine
  • Bupropion
  • Buspirone
  • Butalbital
  • Butorphanol
  • Butylone
  • Butyryl fentanyl
  • BZP
  • Carbamazepine
  • Carfentanil
  • Carisoprodol
  • Cathinone
  • Chlordiazepoxide
  • Chlorofentanyl
  • Chlorpheniramine
  • Chlorpromazine
  • cis-3-Methylfentanyl
  • Citalopram
  • Clobazam
  • Clomipramine
  • Clonazepam
  • Clonazolam
  • Clonidine
  • Cocaethylene
  • Cocaine
  • Codeine
  • Cyclobenzaprine
  • Cyclopropylfentanyl Delorazepam
  • Desalkylflurazepam
  • Desmethylloperamide
  • Desvenlafaxine
  • Dextromethorphan
  • Dextrophan
  • Diazepam
  • Dibutylone
  • Diclazepam
  • Digoxin
  • Dihydrocodeine/Hydrocodol
  • Diphenhydramine
  • Doxepin
  • Doxylamine
  • Duloxetine
  • EDDP
  • Estazolam
  • Ethanol
  • Etizolam
  • Etomidate
  • Eutylone
  • Fentanyl
  • Fluaprazolam
  • Flubromazepam
  • Flubromazolam
  • Flunitrazepam
  • Fluoxetine
  • Flurazepam
  • Fluvoxamine
  • Furanyl fentanyl
  • Gabapentin
  • Galantamine
  • Glipizide
  • Glyburide
  • Haloperidol
  • Hydrocodone
  • Hydromorphone
  • Hydroxyethylflurazepam
  • Hydroxytriazolam
  • Hydroxyzine
  • Ibuprofen
  • Illoperidone
  • Imipramine
  • Isopropanol
  • Isotonitazene
  • Ketamine
  • Lamotrigine
  • Levamisole
  • Levetiracetam
  • Lidocaine
  • Loperamide
  • Lorazepam
  • LSD
  • Lurasidone
  • mCPP
  • MDA
  • MDEA
  • MDMA
  • MDMB-4en-PINACA
  • MDPV
  • Meclonazepam
  • Memantine
  • Meperidine
  • Mephedrone
  • Meprobamate
  • Mescaline
  • Metaxalone
  • Metformin
  • Methadone
  • Methamphetamine
  • Methanol
  • Methaqualone
  • Methcathinone
  • Methocarbamol
  • Methoxyacetyl fentanyl
  • Methylone
  • Methylphenidate
  • Metonitazene
  • Metoprolol
  • Midazolam
  • Mirtazapine
  • Mitragynine
  • MMB-FUBINACA
  • Morphine
  • Naloxone
  • Naltrexone
  • Naproxen
  • N-ethylpentylone
  • Norbuprenorphine
  • Norcyclobenzaprine
  • Nordiazepam
  • Norfentanyl
  • Norflunitrazepam
  • Norketamine
  • Norpseudoephedrine
  • Nortriptyline
  • Norverapamil
  • o-Desmethyltramadol
  • Olanzapine
  • Orphenadrine
  • Oxcarbazepine
  • Oxazepam
  • Oxycodone
  • Oxymorphone
  • Paroxetine
  • PCP
  • Pentazocine
  • Pentobarbital
  • Pentylone
  • p-Fluoro fentanyl
  • p-Fluorobutyryl fentanyl
  • Phenazepam
  • Pheniramine
  • Phenobarbital
  • Phentermine
  • Phenytoin
  • Pimozide
  • Pregabalin
  • Prochlorperazine
  • Promethazine
  • Propranolol
  • Pseudoephedrine
  • Pyrazolam
  • Pyrovalerone
  • Quetiapine
  • Risperidone
  • Salicylic acid
  • Secobarbital
  • Sertraline
  • Strychnine
  • Sufentanil
  • Temazepam
  • Tetrahydrofuran fentanyl
  • Tetrahydrozoline
  • TFMPP
  • Thioridazine
  • Tianeptine
  • Tizanidine
  • Topiramate
  • Tramadol
  • Trazodone
  • Triazolam
  • Trimipramine
  • U-47700
  • Valeryl fentanyl
  • Varenicline
  • Venlafaxine
  • Verapamil
  • Warfarin
  • Xylazine
  • Zaleplon
  • Ziprasidone
  • Zolazepam
  • Zolpidem
  • Zopiclone

Methodology

Screening:

A combination of Ultra-High-Pressure Liquid Chromatography (UHPLC) coupled to Orbitrap based tandem Mass Spectrometry (MS/MS), UHPLC-TripleQuad (QqQ) MS/MS, and 2-column Headspace Gas Chromatography coupled to flame ionization diction (HS-GC-FID).

Confirmation:

UHPLC-TripleQuad (QqQ) MS/MS confirmatory, quantitative methods and 2-column Headspace Gas Chromatography coupled to flame ionization diction (HS-GC-FID).

Assay Availability

Screening for this assay is setup Mon., Wed., and Fri. while quantitative confirmations are run Mon-Fri.

Results Reported

Typically, ≤ 4 business days from receipt for negative reports. For positive, quantitative reports ≤ 8 business days TAT from receipt.

Acceptable Matrices

Whole Blood; 2 x 4 mL Sodium Fluoride (grey top; preferred) or EDTA (purple top) tubes. Any non-retrievable specimen will be considered.

Storage

Stored at 4oC until testing is completed. Long term storage of samples (1 year) is stored at -20oC.

Causes for Rejection

  • Identifiers on the specimen DO NOT match, when compared with the requisition.
  • Specimen handling has compromised the integrity of the specimen (e.g., not stored, or prepared according to testing requirements; frozen specimens and specimens fixed/processed in alternative fixatives)
  • Specimen quality is compromised at or beyond ability to complete testing and provide accurate results (i.e., quality not sufficient [QNS]).
  • Serum-separated specimens.

Laboratory Contact

For further information, please call the MolecularDx Laboratory at 814-361-6997 or email info@molecdx.com.

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